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Among the neurotoxic mechanisms leading to neuronal death, a prominent role is played by the excessive stimulation of NMDA glutamatergic receptor and increased Ca 2+ influx

In particular, RONS and inflammation mutually influence to give rise to a vicious cycle that drives synovial proliferation, angiogenesis, articular cartilage degradation and bone wreck in RA [17, 18]

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It is essential to ask your functional doctor to determine precisely why you are carrying excess weightis it hormonal, inflammatory, due to insulin resistance, or high leptin