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For researchers, the implication is that retatrutides additional GCGR arm appears to contribute incremental effects beyond dual incretin agonism alone, consistent with preclinical energy-expenditure hypotheses, though cross-study comparisons must be interpreted with caution because trial designs, cohorts, and endpoints differ

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Some patients benefit from weekly injections, while others may only need them monthly

doi: 10.1038/nature05859 77 YangWSSriRamaratnamRWelschMEShimadaKSkoutaRViswanathanVSet al

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