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Semaglutide and tirzepatide reduced the risk of hospitalization for HFpEF and all-cause mortality by 40% compared to subjects who took the blood sugar medication sitagliptin, commonly sold under the brand name Januvia

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These medications may be appropriate in specific medical contexts, but they also carry real risks and tradeoffs

Together, their complementary mechanisms suggest a theoretical synergy that targets different fat depots through entirely different biological pathways

The right choice depends heavily on circumstances specific to each person considering treatment