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Since oxidative stress and inflammation are closely associated with insulin resistance, it is conceivable that the AGE-RAGE system may play a role in pathogenesis of insulin resistance observed in PCOS [30], regardless of circulating glucose levels, weight and obesity

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[7] Numerous pharma side effects, but natural alternatives exist However, pharmaceutical GLP-1 agonists are rife with severe side effects, ranging from gastrointestinal distress to muscle loss to excessively long stomach emptying (gastroparesis) to risk of cancer and even blindness

After 68 weeks, 16% reduction in body weight was noted in those who had received the drug, versus 5.7% in the placebo cohort

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STUB1 regulates TFEB-induced autophagy-lysosome pathway