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Primary outcomes Compared to SGLT2i monotherapy, combination therapy with SGLT2i and GLP-1RA was associated with a lower risk of the primary composite outcome (HR, 0.87
J Controll Release: Off J Controll Release Soc
It also supports aerobic metabolism in skeletal muscle and mitochondrial energy production, helping reduce fatigue during and after prolonged efforts
By combining multidisciplinary expertise with high accessibility and ongoing patient interaction, the model aims to support sustainable obesity treatment and long-term health improvement
Decreased butyrate alters the immune function and intestinal permeability of the intestinal mucosa, leading to a compromised intestinal barrier, where bacteria and their metabolites can enter the bloodstream and reach the distant target tissues of the host, resulting in local inflammation and aggravating arthritis (He et al., 2022)
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