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When Arnold first noticed the change in her sense of taste, she wondered, "If food isn't going to make me happy anymore, what is?" she says

Time to vaginal opening was delayed in females at the highest dose, but there were no drug effects on fertility when the animals were mated beginning on day 85 of age

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8.2 The Saturation Hypothesis From SURPASS-CVOT SURPASS-CVOT compared tirzepatide directly with dulaglutide and met its prespecified noninferiority margin but not formal superiority (HR 0.92, 95.3% CI 0.831.01

In the CNS, GLP-1 also exert neuroprotective and neurotropic effects by binding to GLP-1R (116)

Small prospective trials of diabetic patients with GLP-1 RAs have shown benefits in improved lung function in non-asthmatic patients and reduction in exacerbations in patients with asthma