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Among the most exciting geroprotective strategies are those that address multiple hallmarks of aging

The first carries meaningful safety risks

The cardiovascular outcomes trials that enrolled tens of thousands of patients with type 2 diabetesincluding LEADER (liraglutide), SUSTAIN-6 (semaglutide), REWIND (dulaglutide), and EXSCEL (exenatide ER)found no significant increase in overall cancer incidence compared to placebo over follow-up periods ranging from approximately two to five years

Athauda D, Maclagan K, Skene SS, Bajwa-Joseph M, Letchford D, Chowdhury K, et al

For anyone thinking about changing their current medication, our patient's guide to switching from semaglutide to tirzepatide has helpful, practical advice

It also slows down gastric emptying, which helps to regulate appetite by making people feel fuller for longer