Athletes should complete the TUE Pre-Check Form to confirm whether they need a TUE before applying
For example, reduced glutathione, the active form of this antioxidant, becomes oxidised (deactivated) as a result of its antioxidant activity, and so requires reduction through glutathione reductase to regain its antioxidant capacity
Mochida Y, Taguchi K, Taniguchi S, Tsuneyoshi M, Kuwano H, Tsuzuki T et al (2003) The role of P-glycoprotein in intestinal tumorigenesis, disruption of mdr1a suppresses polyp formation in Apc(Min/+) mice
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Repeated activation of the receptors can lead to upregulation and sensitization, causing hyperexcitability of the receptor even at low levels
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