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However, the combined use of metformin and simvastatin may alter this metabolic pattern

Microsatellite instability is associated with the presence of lynch syndrome pan-cancer

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One potential mechanism is the Nrf2-ARE pathway, which induces a phase 2 detoxification response that promotes disruption of Nrf2-Keap protein interactions, translocation of Nrf2 to the nucleus, and regulation of target gene expression through the ARE, enhancing cellular defense against oxidative damage (Sharma et al., 2010)

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Excess melanin in the skin leads to hyperpigmentation, dark spots and uneven skin tone