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Sterol regulatory element-binding protein 2 (SREBP) is positively transcribed by T 3 , which allows SREBP to enter the nucleus and activate the transcription of the LDL-R and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) genes [57]
T.LerinC.HaasW.GygiS
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doi: 10.1016/S0891-5849(01)00480-4 63 SchmittgenT
Frankly, I was among the people who thought five years ago, therell never be small molecules here, because the site youve got to bind is just too big, says Gellman, but he concedes it looks like he was wrong
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