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In turn, these repeated expressions can lead to what are known as dynamic wrinkles , such as frown lines, forehead lines, and crows feet

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A notable example is Petasites japonicus-derived EVs (PJ-EVs), which significantly promote dendritic cell (DC) maturation by upregulating surface markers (CD80, CD86, MHC-I, MHC-II), enhancing Th1-polarizing cytokine secretion (TNF-, IL-12p70), and improving antigen presentation capacity while reducing antigen uptake

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