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Hence, pharmaceuticals that target the NRF2 pathway can influence multiple pathways involved in the neurodegenerative process, and therefore hold potential to become therapies that can significantly modify the course of neurodegenerative diseases
Moreover, the expression of signal transducer and activator of transcription 5A ( STAT5A) , an essential mediator of IL-2 signaling in T-cells ( Figure 6 Most intriguingly, the expression of T H 17-related genes such as IL17A, IL17F, IL22 , and B-cell activating transcription factor (BATF) was strongly decreased by SFN, while T H 1, T H 2 or Treg related genes, i.e., STAT4, IL-4 , and FOXP3 were no major targets of SFN (Figure 6C)
Statistical analyses were performed with GraphPad Prism
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For 5mg/ml concentration charts , the measurement precision demands careful attention
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