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GSH depletion further leads to activation of NF-B and increased pro-inflammatory gene transcription and cytokine release from histone deacetylase suppression in epithelial cells (268, 351)

Because of the slowed gastric emptying, many patients have gastrointestinal side effects that can often limit a patients ability to take these drugsespecially at the high doses recommended for weight loss

Key indicators include hepatic function tests, oxidative stress markers (malondialdehyde, 8-OHdG), and systemic inflammation parameters

In humans, CYP3A is readily induced by xenobiotics, is activated by CYP3A inducers, and leads to activation of PXR (Kliewer 2003

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[PubMed] [Google Scholar] 25.Kim T.K., Karantysh G.V., Mendzheritski A.M., Ryzhak G.A