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Objective measurements (EEG, cardiovascular, and respiratory parameters) and subjective ratings (visual analog scales, awakening times) showed, assessed by Mann-Whitney U test, a normalization of severely disturbed sleep to normal sleep patterns

772, 773, 1225 Tiwari, S

Consider this landmark study from 2011 which has been cited by over 600 other papers

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While cardiovascular death alone didn't reach statistical significance (middle-left panel), consistent directional benefits appeared across heart failure outcomes and all-cause mortality, suggesting broad cardiovascular protection