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The SURMOUNT clinical trial program demonstrated weight loss results that shocked even the researchers running the studies, with participants on the highest dose losing an average of 22.5% of their body weight over 72 weeks
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The half-life of tirzepatide is about 5 days, which means steady state arrives around week 3 to 4 at each dose
Gastric emptying refers to how quickly food leaves the stomach and enters the small intestine for further digestion and absorption
Common Side Effects The most common side effects experienced by patients include: Nausea (typically mild to moderate and often improving with continued use) Fatigue (may diminish as your body adjusts to the medication) Less Common Side Effects Vomiting Constipation Abdominal pain Headache Upset stomach Dizziness Bloating Belching and gas Gastroenteritis (stomach flu) Heartburn Upper respiratory symptoms (runny nose, sore throat) Rare Side Effects Burning sensation in the chest or stomach Indigestion Stomach upset Tenderness in the stomach area Most side effects are temporary and tend to decrease in intensity as your body adapts to the medication
In the pool of seven clinical trials in adults, the types and frequency of common adverse reactions, not including hypoglycemia, were similar to those listed in Table 1
