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Furthermore, weight reduction, especially in overweight individuals, can be associated with decreased insulin and inflammatory mediators, which also contributes to improved brain function [187]

In RCTs, there are tightly regulated cohorts based on stringent in- and exclusion criteria, thereby reducing generalizability

Isoniazid-induced hepatotoxicity is considered idiosyncratic i.e

17 studies were initially identified, but 10 studies were excluded due to lacking or unusable data

& Gladman, D

Knee kinematics (clinical measurements) demonstrated improvements in movement, knee mechanics and quality of life equivalent or better than published data for total knee replacement