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The Phase 2 trial published in The New England Journal of Medicine enrolled 338 participants across multiple dose groups plus placebo

The injection helps to reduce the body's appetite, resulting in the patient consuming fewer calories and having less energy to store as fat

Its classified as a pentadecapeptidemeaning it contains 15 amino acidsand its designed to support tissue repair and reduce inflammation throughout the body

Once-weekly IcoSema was evaluated in the phase 3a COMBINE programme, comprising three 52 week, multinational, multicentre, randomised, open-label trials in individuals with type 2 diabetes (COMBINE 13)

1995 Dec:29(12):1263-73. [PMID: 8672832)