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It is essential not to misread that move: removal from the significant-risk category is not an approval, does not establish safety, and does not by itself authorize compounding the agency framed it as a procedural step ahead of a formal advisory review, not as a safety endorsement
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In ATDC5 chondrocytes derived from mouse teratocarcinoma cells and stimulated with IL-1 to simulate the osteoarthritis cellular environment, catalpol significantly reduces matrix metalloproteinases (MMP-1, -3, -13) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS-4, -5), demonstrating anti-cartilage degradation activity (Yin et al., 2024)