Furthermore, iron accumulation is even higher in the substantia nigra in Parkinsons disease (PD) and in anatomical regions affected by -amyloid plaques and tau protein loading in Alzheimers disease (AD) suggesting iron overload as a key factor in the pathogenesis of common neurodegenerative diseases [80, 81]
For patients already meeting indications for use of a GLP-1 drug based on metabolic factors, its potential role in lowering uveitis risk could be an added consideration when selecting antihyperglycemic therapy. 1 While these possibilities are positive advancements, a commentary on the study, also published yesterday in JAMA Ophthalmology , provides some potential limitations to keep in mind when interpreting conclusions
These glial cells express adenosine receptors and are susceptible to the effects of caffeine [90]

The intensive treatment of the multiple risk factors reduces the development/progression of renal disease18 which is why guidelines insist on comprehensive management of the patient with diabetes (glycemic control and control of cardiovascular risk factors, use of renin-angiotensin system inhibitors, as well as lifestyle changes, including smoking cessation or weight loss in overweight/obese individuals, among others).19 However, the residual renal risk remains very high in optimally treated patients.20 More recently, iSGLT2 has been shown to reduce the risk of cardiovascular and renal events, but still, the residual risk of renal disease progression remains high.21,22 Nevertheless, although the rate of diabetes-related complications (such as myocardial infarction, stroke, lower limb amputations or mortality) have decreased significantly in recent decades, this is not the same for CKD patients requiring renal replacement therapy attributed to diabetic kidney disease (DKD).23 Therefore new treatments are needed that improve glycemic control independently of GFR, with a low risk of hypoglycemia and able to reduce cardiovascular and renal risk in this population

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