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Proteomic analysis showed that these significantly differentially expressed proteins are involved primarily in metabolic pathways including carbon metabolism, amino acid biosynthesis, pyruvate metabolism, glucagon signaling, pentose phosphate pathway, HIF-1 signaling and glycolysis/gluconeogenesis (Figure 4C)

Conclusions CHE is a multifactorial condition characterized by overlapping clinical subtypes and significant societal burdens [5]

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Chemokines like CCL2, CCL5, and CXCR4 also appeared to be less expressed, along with a possible reduction in gp91phox, a component involved in oxidative stress

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