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RAW264.7 cells were transfected with Apollo-NADP + sensors targeted to the mitochondria or the cytosol, followed by the treatment of 2-deoxyglucose and diamide

They are produced by plants often as phytoalexins (defense compounds in response to stress or infection) (14)

More specifically, genetic toxicology testing returned negative results across the board

J., Yaden, B

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Aside from cytosolic amino acid sensors, intra-lysosomal amino acid sensing coincided with the identification of SLC38A9, a lysosomal transmembrane protein likely belonging to arginine transporters and an integral part of mTORC1 activation via Ragulator-RAG GTPases (Jung et al., 2015