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2.4.1.1 Effects of ISL on hepatic oxidative stress ISL pretreatment prevented from triptolide-induced hepatotoxicity by inhibiting MDA and restoring the levels of glutathione, glutathione peroxidase (GPX), SOD and catalase (CAT) via activation of the Nrf2 pathway in an acute liver injury model (Cao et al., 2016)

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Preclinical models have long implicated 5-HT and DA dysregulation in ethanol-related affective disturbances