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SGLT-2 inhibitors retain adjunctive roles, often combined for cardiorenal protection, while amylin analogues remain niche given specificity to postprandial control
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That said, Zepbound label does include a warning to monitor patients for emergence or worsening of depression, suicidal thoughts or behaviors, and unusual changes in mood
These effects often accompany the primary bowel changes and reflect the medication's impact on digestive function
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