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PGE2, Prostaglandin E2

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Chronic activation of GLP-1R further upregulates fibronectin type III domain-containing 5 (FNDC5)/irisin and uncoupling protein 1 (UCP1), supporting the rationale for BAT-targeted polymer-lipid hybrid NPs co-loaded with 3-adrenergic agonists to amplify thermogenic energy expenditure [241]

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