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GI adverse events (nausea, diarrhea, vomiting) mostly mild to moderate

Molecular structure of DPP-4 DPP-4 has two domains and two subdomains: / hydrolase domain (Gln508-Pro766), -propeller domain (Arg54-Asn497), receptor binding subdomain, and a core subdomain [15]

If not treated, bowel obstruction could be fatal

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Sclerostin (SOST) is a secreted protein produced by osteocytes that binds to LRP5/6 to inhibit Wnt signal transduction, thereby inhibiting bone formation

CHO-hCB 1 cells were treated by concomitantly adding THC and the test compound for 45 min