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Glutathione alterations in depression: a meta-analysis and systematic review of proton magnetic resonance spectroscopy studies

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The lack of cortisol stimulation is particularly advantageous, as chronic cortisol elevation can lead to numerous adverse effects including immune suppression, bone loss, and metabolic dysfunction

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However, positive controls using either recombinant GH (to mimic the downstream GH-receptor-mediated step) or IGF-1 are important to distinguish GHS-R1a direct effects from GH-axis-mediated effects