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Efficacy and safety of berberine alone for several metabolic disorders: A systematic review and meta-analysis of randomized clinical trials. Frontiers in Pharmacology, 2021

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The active ingredient in Wegovy is semaglutide, and dulaglutide in Trulicity

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In a retrospective analysis of 177 patients on oral semaglutide, weight loss velocity decelerates sharply after 3 months from 1.99 kg/month in the first month to 0.18 kg/month between months 6 and 12 and a 23% weight rebound is already measurable by month 18 (Makkar et al., 2026)

While it is unknown if this occurs in humans, those with a personal or family history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should not use these medications