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More recently, studies with larger sample sizes and superior study design have demonstrated a significantly increased risk of ASCVD associated with G6PD-d

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Steps to reduce the risk of and manage metformin-associated lactic acidosis in these high-risk groups are provided in the full prescribing information [see Dosage and Administration (2.1 and 2.4), Contraindications (4), Warnings and Precautions (5.1), Drug Interactions (7), and Use in Specific Populations (8.6, 8.7)]

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Luongo TS et al (2015) The mitochondrial calcium uniporter matches energetic supply with cardiac workload during stress and modulates permeability transition

January 10, 2024