While the trial was not designed to formally disentangle weight lossmediated vs weightindependent mechanisms, the magnitude and durability of weight loss likely play a substantial role in risk modification. Clinicians should note that in SELECT, treatment discontinuation due to adverse events was 16% on semaglutide vs 8% on placebo, largely driven by GI events
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The relationship between impaired immunological memory and CoV proteins in the live virus needs to be further explored
monitoring TSH 68 weeks after initiation helps guide adjustments
This corresponded to a NNH of 1,198, indicating that approximately one additional case of psoriasis would occur for every 1,200 patients treated with GLP-1 RAs instead of DPP-4is
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