Association Between GLP-1 Receptor Gene Polymorphisms with Reward Learning, Anhedonia, and Depression Diagnosis. Acta Neuropsychiatrica, vol
Patient safety guidance should include: Education about expected appetite changes and strategies for maintaining adequate nutrition Monitoring for excessive weight loss or signs of malnutrition Assessment of mental health at follow-up visits Clear instructions to report severe or persistent nausea, vomiting, or neuropsychiatric symptoms Awareness that cognitive effects remain investigational and should not influence prescribing decisions Reporting severe persistent abdominal pain (pancreatitis), right upper quadrant pain/jaundice (gallbladder disease), severe abdominal distension with inability to pass gas or stool (possible ileus), persistent vomiting or signs of dehydration, and new/worsening vision changes (retinopathy) Understanding increased hypoglycemia risk when combined with insulin or sulfonylureas GLP-1 receptor agonists are contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, and should be used with caution in patients with severe gastrointestinal disease, including gastroparesis
"It includes how to eat healthy (and what to do if you dont), how to get restful sleep, getting physical activity, adequate water intake and daily stress relief. Limit processed foods and sugar: Eating a balanced diet rich in whole foods can make a huge difference when it comes to maintaining a healthy weight, lowering the risk of chronic diseases like heart disease and diabetes, and improving energy levels
5.4% WL with 14 mg oral semaglutide after 68 weeks at the PIONEER PLUS trial (Fig
Schedule meals even if not hungry (aka mechanical eating) Focus on hydration, especially with nausea or low intake
3) Technology can be useful in people with type 2 diabetes but needs to be part of an holistic plan of care and supported by DSMES
