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PLC mediates the conversion of PIP into membrane-bound diacylglycerol (DAG) and soluble inositol 1,4,5-trisphosphate (IP)

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The reason for the cardiovascular benefit may be that SGLT2i not only have a significant impact on circulating biomarker levels of in diabetic patients with HFpEF, but also ameliorate the deterioration of cardiac function [54, 55]

PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: A basis for circadian transcription

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