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In glutamate-treated HT22 cells, both NE and DA significantly suppressed glutathione depletion-associated mitochondrial dysfunction including mitochondrial superoxide accumulation, ATP depletion and mitochondrial AIF release

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AOD9604 acts directly on fat metabolism but doesnt meaningfully raise HGH or IGF1 levels (human safety data)

doi: 10.1056/NEJMoa1003114

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Conversely, for individuals with HIV lipodystrophy treated with tesamorelin, GH and IGF-I levels are increased but insulin sensitivity remains preserved