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SIRT1 through interaction with heat shock protein A4 (HSPA4) represses the expression of pro-inflammatory cytokines

Long-term use of cortisone injections can cause various side effects, including tissue atrophy, weakened tendons, and blood sugar elevation

Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability

Future studies should explore the dynamic interactions among SIRT1, mTOR, autophagy, and endoplasmic reticulum (ER) stress to elucidate its regulatory functions under varying metabolic states, guiding the development of targeted interventions for early-stage MASLD-related metabolic disorders

Silver Spring (MD): National Institutes of Health (2016)

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