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Combined with other internal sources of oxidative stress, like inflammation and psychoemotional stress, and external sources, like ultraviolet radiation, we get a buildup of oxidative stress over decades that may cause our melanocytes, the pigment-producing cells, to age and die off

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Sulfite is then released upon reduction of this intermediate that is mediated by GSH and the cysteines of the CxxC motif (Cys385 and 388 in AtAPR1) present in the C-terminal GRX-like domain

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A proposed explanation is that iron is essential for the activity of tyrosine hydroxylase, the enzyme responsible for dopamine synthesis

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