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B12 is water-soluble, and excess amounts are typically excreted by the body

Differential structural properties of GLP-1 and exendin-4 determine their relative affinity for the GLP-1 receptor N-terminal extracellular domain

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"Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase." Journal of Medicinal Chemistry

B12 is often added to support normal energy metabolism

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