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Heavy drinking depletes hepatic glutathione by 5080% within hours, creating a bottleneck where acetaldehyde accumulates faster than ALDH2 can clear it

10.1093/humrep/dei001

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Selenop / / Scly / mice, indicating exacerbated neurological phenotype compared to Selenop / mice, including motor coordination, audiogenic seizures, and brainstem neurodegeneration