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Given the harmful effects of eryptotic RBCs on endothelial cells and platelets, which can cause vascular inflammation and blood coagulation, these studies provide a rationale that links cigarette smoke to vaso-occlusive complications and atherogenesis

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Although challenges such as limited bioavailability and safety concerns continue to impede clinical translation, these limitations may be addressed through the optimization of delivery strategies, rigorous pharmacokinetic and toxicological assessments, mechanism-driven in vitro , in vivo , ex vivo studies, and well-designed clinical trials

Additionally, TK links this pathway to glycolysis, which enables the cell to adapt to its metabolic needs (, )