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Phase I metabolism of dihexa, which was determined using pooled male rat liver microsomes, was found to be veiy low with an average intrinsic clearance (Clin t ) of 2.72 7/ and an average half-life of 509.4 minutes

Compounds that can either stabilize NRF2 or inhibit KEAP1, thereby enhancing NRF2's antioxidative response, are under investigation for their potential neuroprotective effects against radiation-induced damage [41]

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In: Albertsson A-C, editor

doi: 10.3389/fphar.2014.00151 Received 27 May 2014 Accepted 10 June 2014 Published 01 July 2014 Volume 5 - 2014 Edited by Alfonso Pompella, Universit di Pisa, Italy Reviewed by Richard Eugene Frye, Childrens Hospital Boston/Harvard Univerity, USA

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