Pfizer terminated lotiglipron in October 2023 due to dose-dependent liver enzyme elevations, and subsequently discontinued danuglipron in April 2025 after a single case of potential drug-induced liver injury was identified in a dose-optimization study
It allows the peptide to build up in the system and saturate the melanocortin receptors
For instance, a study in Nutrients highlights that diets high in fruits and vegetables are associated with improved potassium intake, which is crucial for cardiovascular health
People who remain on GLP-1 therapy for 1224 months (rather than stopping after 6 months) show better long-term weight maintenance because their brains have more time to adapt to lower body weight
Improved metabolic health: These medications not only help with weight loss but can also improve blood sugar levels, cholesterol, and blood pressure, all of which can reduce your risk of heart disease, stroke, and other chronic conditions
Genome-wide association study (GWAS) data for AF were sourced from FinnGen10, whereas data for cardiac arrest and ventricular fibrillation came from the GWAS Catalog
