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Lead series optimization Our goal was to enhance interactions of the small-molecule agonists with the GLP-1R through lowering the energy barrier to achieve the receptor-bound agonist conformation, and by adjusting polar substituents, with minimal increases in molecular weight

FDAs decision on whether to approve Orforglipron, Eli Lillys daily pill, is expected in April, Reuters reported

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For instance, Clayton AH, et al

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