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However, the enzyme can, under certain conditions, also inactivate cortisol and corticosterone by catalyzing the oxidation reactions converting cortisol to cortisone and corticosterone to 11-dehydrocorticosterone

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The following parameters were recorded using the EthoVision software: the locomotor activity, the number of approaches made toward the novel and familiar objects, and the time spent near them

That's on the aggressive end, and there's no human dose-finding data backing that specific number for the TB-500 fragment