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These cytokines can promote cognitive dysfunction as they are able to disrupt the blood-brain barrier (BBB), allowing proinflammatory cytokines (355) to translocate into the brain and promote inflammation ( Figure 10 )

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Las personas que tienen una afeccin poco comn llamada sndrome de neoplasia endocrina mltiple tipo 2 (MEN2) tampoco deben usarlo, y lo mismo se aplica a quienes tienen antecedentes de pancreatitis o enfermedad de la vescula biliar

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