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S1 in the supplementary material), which meant that participants could have their end-of-study (EOS) visit beyond 44 weeks

PCOS patients have an increase in the oxidative stress with generation of excessive amounts of reactive oxygen species (ROS) and reduction of antioxidant capacity [26]

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Depletion and other background things as you mention are possible, as well as the B-Vits triggering some detox that has been waiting

As a novel multi-agonist peptide, it acts on GLP-1, GIP, and glucagon receptors, three key pathways involved in appetite regulation, glucose metabolism, and fat utilization

While there is promise, we need more data to conclude