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Yang WL, Zhang CY, Ji WY, Zhao LL, Yang FY, Zhang L, et al

In individuals with obesity or metabolic dysfunction, this hormonal signaling system often does not function optimally, leading to persistent hunger, frequent cravings, and difficulty achieving satiety even after eating adequate meals

Orforglipron showed higher rates of adverse side effects such as nausea, vomiting and other gastrointestinal issues compared with semaglutide

Additionally, glucose-mediated G6PD inhibition resulted in elevated ROS in podocytes resulting in podocyte injury [33], a complication of diabetes that can lead to diabetic kidney disease [35]

Ethics declarations Competing Interest The authors declare no conflict of interest

Participants with class III obesity (BMI 40 or higher) were more likely to be late responders, meaning they needed more time to achieve significant weight loss