We found that administering 80-nM GLP-1 significantly counteracted the inhibitory effect of pasireotide on high glucose (20 mM)-induced insulin production, aligning with the cAMP levels in GLP-1R-MIN-6 cells
Thus GLP-1 was shown to regulate a number of diverse functions: reduction in digestive enzyme secretion, slowing of gastric motility, increases in heart rate and blood flow, increased bone remodeling, and suppression of appetite (via hypothalamic and brainstem nuclei)
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