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10.3389/fphar.2022.1043283 121 ZhaL.LiuR.SobueT.KitamuraT.IshiharaJ.KotemoriA.et al (2021)

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Additionally, there's interest in investigating how FOXO4-DRI might work in conjunction with other senolytic agents or treatments to combat age-related diseases more effectively

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In HCC patients, a large proportion of infiltrating CD11b-CD27-NK subset cells in tumor origin exhibit an inactive and immature phenotype, with weak cytotoxicity and decreased IFN- production ability, hence closely related to clinical outcomes [46]