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Alhalabi H, Borschel L, Le Foll C, Thomas A, Bally L, Thevis M

This shift toward MC4R selectivity makes PT141 a useful tool for isolating MC4Rmediated signalling including Gproteincoupled cAMP and phospholipaseC cascades, intracellular calcium flux, and ERK/MAPK pathway activation within neuronal and receptorexpressing model systems

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If this structure is disrupted, it can lead to premature dilation and potential preterm birth

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However, in early stages it is often successfully treated