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The SURMOUNT-4 trial found that patients who continued tirzepatide 15 mg lost an additional 5.5% of body weight over 52 weeks, while those switched to placebo regained approximately 14.0% (Aronne et al., JAMA 2024)

The FDA approves medications for specific indications based on clinical trial evidence

Semaglutide causes delayed gastric emptying in both scenarios, says Kadaj

The BMI thresholds for GLP-1 prescribing are well-established and provide a clinical framework for initiating treatment

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