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Whilst oral bioavailability is relatively poor (less than 5% reaches systemic circulation due to extensive first-pass metabolism), sufficient absorption occurs to produce measurable pharmacological effects in research settings

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doi: 10.1038/s41598-022-17000-w 48 LiZLinMLiuCWangDShiXChenZet al

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That means their safety and effectiveness have not been tested, so there is no guarantee as to what ingredients they actually contain