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An early clinical trial in 13 patients with type 2 diabetes found that a single intravenous infusion of 1,000 mg of lipoic acid improved insulin-stimulated glucose disposal (i.e., insulin sensitivity) by 50% compared to a placebo infusion (57)

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doi:10.1002/14651858.CD007411.pub5 El Sharkwy I, Sharaf El-Din M

The oral form is a coherent system here the route of exposure coincides with the first link of the brain-gut axis